Radiosynthesis of Tricarbonal Rhenium~(188)Re

The complex of N(Et)42Re(CO)3Br3 is prepared and characterized by IR, ICP-MS, elemental analysis. When the complex is dissolved in water, the three Br- ligands are quantitatively exchanged by three water molecules and the precursor of fac-Re(H_2O)_3(CO)_3+ can be obtained. The complex of fac-188 Re(H_2O)_(CO)_3+ is synthesized with an overall radiochemical yield of 80%, and with more than 95% radiochemical purity after Sep-Pak separation. The complex of fac-Re(H_2O)_3(CO)_3+ taken as a standard sample, the structure of the precursor, fac- 188 Re(H_2O)_3(CO)_3+, is confirmed by HPLC.