STUDY OF NEW ~(113m)In-BAT COMPLEXES FOR MYOCARDIAL IMAGING AGENTS——SYNTHESIS OF LIGANDS. CRYSTAL STRUCTURE AND BIODISTRIBUTION

In this paper, some new BAT derivatives are designed and synthesized in order to find some ideal myocardial imaging agents. These ligands form penta-coordinated complexes with indium cation. The structures of ligand BAT-TE and complexes In-BAT-TE and In-BAT-ETE are determined by X-ray crystallography at first. Biodistribution shows that the higher lipophilicity of complex induces apparently higher myocardial accumulation. Up to date, complex B is the best 113mIn-labeled myocardial imaging agent. It is also suited to 111In.