THE SYNTHESIS OF TETRA (2-METHOXY ISOBUTYL ISONITRILE) CUPROUS BOROFLUORIDE AND THE PREPARATION OF ~(99)Tc~m-MIBI
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Graphical Abstract
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Abstract
The synthesis of Cu(MIBI)4BF4, the preparation of 99Tcm-MIBI and the animal studies are reported in this paper. Cu(MIBI)4BF4 is a white solid. The IR,NMR,MS and elementary analysis are consistent with the structure of Cu(MIBI)4BF4. It also discusses the effects of pH value, weights of Cu(MIBI)4BF4 and FSA,volume of 99TcmO4- solution and heating time on the labelling yields of 99Tcm- MIBI. From the kit made of Cu(MIBI)4BF4 ,the labelling yields of 99Tcm-MIBI are over 90%. The animal studies and preliminary clinical application are proved that 99Tcm-MIBI is a potentially useful myocardial perfusion imaging agent.
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