LABELLING CEA-McAb WITH ~(211)At AND ITS PRELIMINARY ANIMAL EXPERIMENT

The synthesis of 211At labelled CEA monoclone antibody is performed by an activating reaction of carboxy via para-astato-benzoic interaction. The 211At-CEA-McAb conjugate is separated by a sephadex G75 column and then analysed and identified by hydrophobic interaction HPLC. It contains at least 30% of initial activity of 211At with the specific radioactivity, up to 3. 7×104 Bq/μg McAb. The stability in vivo of the conjugate is discussed by determining dynamic curve in mouse blood and other tissues.