FULLY AUTOMATED SYNTHESIS OF O-(2-~(18)F-FLUOROETHYL)-L-TYROSINE

18F- is produced via nuclear reaction 18O(p,n)18F at PET trace Cyclotron. O(218Ffluoroethyl)Ltyrosine(18FFET) is synthesized by a twostep reaction at FDG MicroLab Synthesis. Nucleophilic fluorination reaction of 18Ffluoride with 1,2di(4methyphenylsulfonyloxy)ethane on column give 218F1(4methylphenylsulfonyloxy) ethane, and 18Ffluoroalkylation of Ltyrosine disodium salt with 218F1(4methylsulfonyloxy) ethane formed 18FFET. The overall radiochemical yield with no decay correction is more than 4%, the whole synthesis time is about 52 min, and the radiochemical purity is above 95%. The synthetic 18FFET can be suitable for clinical study with PET imaging.