SYNTHESIS, ~(99)Tc~m-LABELED AND BIODISTRIBUTION STUDY OF γ-THIOUREIDOPROPYL GERMANIUM SESQUISULFIDE[J]. Journal of Nuclear and Radiochemistry, 2002, 24(4): 240-240.
    Citation: SYNTHESIS, ~(99)Tc~m-LABELED AND BIODISTRIBUTION STUDY OF γ-THIOUREIDOPROPYL GERMANIUM SESQUISULFIDE[J]. Journal of Nuclear and Radiochemistry, 2002, 24(4): 240-240.

    SYNTHESIS, ~(99)Tc~m-LABELED AND BIODISTRIBUTION STUDY OF γ-THIOUREIDOPROPYL GERMANIUM SESQUISULFIDE

    • A new organogermanium sesquisulfide is synthesized and identified by IR spectrum and elemental analysis method.The new compound is labeled by 99Tc m and the labeling yield is 84.2% under the best condition (ligand, 0.5 mg; SnCl 2, 0.1 mg; pH≈8.0; reaction temperature, 20 ℃; reaction time, 20 min). The biodistribution experiments in mice of the 99Tc m labeled compound show that it is mainly concentrated in lung,next in liver.When the mass concentration of the labeled compound is 50 μg/mL,its antitumor activity against KB,HCT and Bel cells in vitro is 69.0%,76.9% and 44.7%,respectively.
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