PREPARATION AND BIODISTRIBUTION OF ~(188)Re-HEDTMP

HEDTMP(N-(2-hydroxyethyl )ethylenediamine-1,1,2-tri(methylene phosphonic acid)) is synthesized and labeled with 188Re.The rabbit bone imaging and mice biodistribution of 188Re-HEDTMP are studied to estimate the possibility of 188Re-HEDTMP as a bone tumor therapeutical.The results show that 188Re-HEDTMP is mainly concentrated in animal skeleton and uptakes of non-target tissues are low.So 188Re-HEDTMP is a promising candidate for bone tumor radiotherapy.