INFLUENCE OF BINDING CHARACTERISTICS OF ~(153)Sm-COMPLEXES TO BSA ON THEIR BONE UPTAKE

The bone uptake in normal mice and adsorption on bone model materials (hydroxyapatite and type I collagen) of 153SmNTMP, 153SmHEDTMP, 153SmDCTMP, 153SmEDTMP, 153SmDTPMP and 153SmDTPA are compared, and then the binding characteristics of these 153Smcomplexes to bovine serum albumin (BSA) are investigated. It is found that there is a discrepancy between the bone uptake and the adsorption on bone model materials, and that the binding characteristics of these 153Smcomplexes to BSA play an important role in the process of their bone uptake. Also, the binding characteristics are applied to explain the discrepancy successfully.