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    SYNTHESIS AND BIODISTRIBUTION OF ~(99)Tc~m MIXED LIGAND COMPLEXES CONTAINING A TRIDENTATE N-(O-METHYLTHIOPHENYL)ETHYLENEDIAMINE AND MONODENTATE THIOLS[J]. Journal of Nuclear and Radiochemistry, 2003, 25(2): 110-110.
    Citation: SYNTHESIS AND BIODISTRIBUTION OF ~(99)Tc~m MIXED LIGAND COMPLEXES CONTAINING A TRIDENTATE N-(O-METHYLTHIOPHENYL)ETHYLENEDIAMINE AND MONODENTATE THIOLS[J]. Journal of Nuclear and Radiochemistry, 2003, 25(2): 110-110.
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    SYNTHESIS AND BIODISTRIBUTION OF ~(99)Tc~m MIXED LIGAND COMPLEXES CONTAINING A TRIDENTATE N-(O-METHYLTHIOPHENYL)ETHYLENEDIAMINE AND MONODENTATE THIOLS

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    • A new ligand N(OMethylthiophenyl)ethylenediamine(MTPEA) is synthesized and characterized by IR, MS(FAB+) and elemental analysis. The preparation of two 99Tcmmixedligand complexes is studied by ligand exchange reaction. At the same time, the optimal conditions for labelling are obtained. The biodistribution study shows that both complexes could thread the bloodbrain barrier and in brain for a certain time.
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