CELLULAR UPTAKE AND THE BIODISTRIBUTION IN TUMOR BEARING MICE OF~(99) Tc~m-MIBI AND ~(99) Tc~m-TETROFOSMIN

The cellular uptake of 99 Tc m MIBI and 99 Tc m tetrofosmin in murine melanoma cell line B16,murine myeloma cell line SP2/0 and normal fibroblast line ME are studied.The results show that the uptake in tumor cells is remarkably higher than in normal cells.The biodistribution of 99 Tc m MIBI and 99 Tc m tetrofosmin in tumor bearing mice are also studied. Although the tumor to blood concentration ratios are fairly high,the overall target specificity is low.