SYNTHESIS AND PRELIMINARY STUDY ON A NEW CLASS ANTI TUMOR AGENTS—CETYTHIOPHENE THIOSEMICARBAZONE

Six 2 acetylthiophene TSC have been synthesized and characterized by IR,MC and elemental analysis.Five of them are the first prepared compounds.The anti tumor activities of them have been investigated. The results show that they have high inhibition to all three carcinoma cells (KB cell,HCT 8 cell and Bel 7402 cell). These ligands are labeled with 111 In.The biodistributions of six 111 In ligand complexes in mice are determined.The results show that concentrating of 111 In ligand complexes in blood is not apparent.Further study is needed to see the uptake of 111 In ligand complexes by carinoma cells.