MULTITRACER STUDY ON IN VIVO AND IN VITRO BINDING OF TRACE ELEMENTS WITH MOUSE LIVER DNA

In vivo,semi in vivo and in vitro binding of a series of trace elements (Be,Sc,Mn,Co,Zn,As,Se,Rb,Sr,Y,Zr,Tc,Ru and Rh)is studied by the multitracer technique.The corresponding nuclides in the multitracer solution used are 7 Be, 46 Sc, 54 Mn, 58 Co, 65 Zn, 74 As, 75 Se, 83 Rb, 85 Sr, 88 Y, 88 Zr, 95 Tc m, 103 Ru and 102 Rh m.It is found that most elements bound mouse liver DNA in vivo except As, Ru and Rh.In the semi in vivo experiment,only elements Rh and As are not observed to be bound with DNA.In the in vitro experiment,DNA bound with all elements,among which Rb,Se,Zr,Ru and As showed very slight binding.In comparison,the binding in vitro is the strongest,semi in vevo the medium and in vivo the weakest.