STABILITY OF ISOMERS OF ~(99)c~m-HM-PAO BASED ON CNDO/2 METHOD

Formation energy,total energy of system and net charge of isomers of 99Tcm-HM-PAO have been calculated by CNDO/2 method. The computed results indicate that the order of stability is meso 2-HM-PAO>d,l-HM-PAO> meso 1-HM-PAO. After cyclation of d,l -HM-PAO, the calculated results show that stability of d,l -CB-PAO is increased rapidly. This study reveals structural features that may be employed to account for disparate pharmacokinetics of the meso and d,l -HM-PAO 99Tcm-radiophar-maceuticals.