STUDIES ON BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS Ⅰ. PREPARATION OF ~(163)Sm AND ~(153)Sm-EDTMP LUO SHUNZHONG PU MANFEI LI YUQIAN LIU ZHONGLIN

In this paper, 153Sm with high radionuclear purity and specific activity (5.18GBq (l40mCi) /mg Sm2O3) is prepared by irradiating natural Sm2O3 (152Sm,26.7%) sample, replacing costly enriched Sm2O3 target, at a flux of 4×1013n·cm-2·s-1 for a period up to 110h. The yield of 153Sm complexes with EDTMP is up to 99% at pH 8-10, in boiling water bath for 30min. The formation of Sm(153Sm)-EDTMP is measured by 153Sm tracer technique. The results show that the ratio of Sm(153Sm)to EDTMP is 1:1.