NEW CHOLESTEROL ANALOGUE AS ADRENAL IMAGING AGENT——SYNTHESIS AND TISSUE DISTRIBUTION OF BROMINE-82 LABELED 6-BROMOMETHYL CHOLESTEROL

6-Bromomethyl cholesterol (CL-6-MeBr) is synthesized from cholesterol by six step reactions. Bromine-82 labeled 6-bromomethyl cholesterol (CL-6-MeBr-82) is prepared by means of hydrothermal melting method. Tissue distribution of CL-6-MeBr-82 in mice is determined. The adrenal uptake of CL-6-MeBr-82 reaches a maximum of 92.08% dose/g at the 5th day after injection, and the adrenal to liver ratio increases from 4.2 at 1 day to 48.72 at five days.CL-6-MeBr-82 shows less affinity for the adrenal gland than CL-6-Br-82.