Radiosynthesis of O-(2-~(18)Ffluoroethyl)-L-tyrosine by Microwave Heating

O-(2-~(18)Ffluoroethyl)-L-tyrosine, recently developed radiolabelled amino acids,is a very promising PET imaging agent for brain tumor diagnosis and holds hugely clinical potential.To(shorten) synthesis time,simplify operation process and lessen irradiation exposure to operator,radiosynthesis of O-(2-~(18)Ffluoroethyl)-L-tyrosine is adapted and optimized,according to three aspects of its two-step method, including reaction components,heating methods and reaction models.Introducing microwave heating,one-pot model and L-Tyr,NaOH-H_2O and DMSO as reactant,the total synthesis time is within 20min.