STUDIES ON THE KINETICS OF LIGAND EXCHANGE REACTION BETWEEN 99mTC-GLUCOHEPTONATE AND t-BUTYLISONITRILE

The cationic complex 99mTc hexakis(t-butylisonitrile)-technetium (Ⅰ)99mTc TBI is a valuable myocardial imaging agent for myocardial ischemia and infarc tion.99mTc-TBI is prepared by ligand exchange reaction between 99mTc-GH and TBI.The ligand exchange reactions are studied at different pH values, time, TBI and calcium glucoheptonate concentrations. The exchange yield is determined by paper chromatography and reaction rate constants are calculated at different pH values.The results obtained show that the ligand exchange between 99mTc-GH and TBI is a second order reaction and the rate constant of the ligand exchange reaction depends on pH values.