Preparation Study of ⁹⁹Tc^m-DTPA-DG

The complex ⁹⁹Tc^m-DTPA-DG is prepared through synthesized DTPA-DG. ⁹⁹Tc^m is used to label diethylenetriaminepentaacetic aciddeoxyglucose ( DTPA-DG ) with stannous chloride reduction. Paper chromatography was performed with acetone and physiological saline as the mobile phase. ⁹⁹Tc^m-DTPA-DG was prepared containing 25mg DTPA-DG and 0.5mg SnCl₂. The pH was subsequently adjusted to 6.0. ⁹⁹Tc^mO^-₄ added at room temperature, 30min later, the radiochemical purity of ⁹⁹Tc^m-DTPA-DG is 99%. The radiochemical purity is 986% when it is stable over 6h at room temperature. DTPA-DG can be labeled with ⁹⁹Tc^m easily, efficiently, and with high radiochemical purity, stability and cost effectiveness.
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