Preparation of 117Snm(113Sn)(Ⅳ)-TPPS4[J]. Journal of Nuclear and Radiochemistry, 2006, 28(2): 111-116.
    Citation: Preparation of 117Snm(113Sn)(Ⅳ)-TPPS4[J]. Journal of Nuclear and Radiochemistry, 2006, 28(2): 111-116.

    Preparation of 117Snm(113Sn)(Ⅳ)-TPPS4

    • Development of 117Snm radiopharmaceuticals with radiosensitization ability to the treatment of tumors is valuable since such agents may increase therapeutic effects. In this paper, 117Snm(113Sn) was prepared by irradiation of spectrally pure natural metallic tin grain with reactor thermal neutrons (neutron fluence rate 4×1013cm-2·s-1) for a period up to 90h, yielding 117Snm and 113Sn with specific activity of 0.13GBq/g and 6.16MBq/g respectively, and meso-tetrakis(4-sulfonatophenyl) porphyrin (TPPS4) was labeled with 117Snm (113Sn) in aqueous solution. The optimized preparation conditions are as follows:pH=2-4, reaction temperature about 100℃, reaction time 30min. Under the recommended experimental conditions, the yield of 117Snm-TPPS4 is higher than 95%. No significant decomposition of the 117Snm-TPPS4 complex solution is observed either during the standing period of 48h after its preparation, or after the dilution of it with physiological saline to 5-15 times at room temperature. A 1∶1 stoichiometry of the 117Snm-TPPS4 complex is obtained by the job’s method.
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