Preparation of 117Snm(113Sn)(Ⅳ)-TPPS4
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Graphical Abstract
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Abstract
Development of 117Snm radiopharmaceuticals with radiosensitization ability to the treatment of tumors is valuable since such agents may increase therapeutic effects. In this paper, 117Snm(113Sn) was prepared by irradiation of spectrally pure natural metallic tin grain with reactor thermal neutrons (neutron fluence rate 4×1013cm-2·s-1) for a period up to 90h, yielding 117Snm and 113Sn with specific activity of 0.13GBq/g and 6.16MBq/g respectively, and meso-tetrakis(4-sulfonatophenyl) porphyrin (TPPS4) was labeled with 117Snm (113Sn) in aqueous solution. The optimized preparation conditions are as follows:pH=2-4, reaction temperature about 100℃, reaction time 30min. Under the recommended experimental conditions, the yield of 117Snm-TPPS4 is higher than 95%. No significant decomposition of the 117Snm-TPPS4 complex solution is observed either during the standing period of 48h after its preparation, or after the dilution of it with physiological saline to 5-15 times at room temperature. A 1∶1 stoichiometry of the 117Snm-TPPS4 complex is obtained by the job’s method.
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