Bifunctional Chelate for Radiolabeling of Biotin With99Tcm(CO)3(H2O)3+

Bifunctional Chelate for Radiolabeling of Biotin With[99Tcm(CO)3(H2O)3]+[J]. Journal of Nuclear and Radiochemistry, 2006, 28(1): 43-48.

Citation:

Bifunctional Chelate for Radiolabeling of Biotin With[99Tcm(CO)3(H2O)3]+[J]. Journal of Nuclear and Radiochemistry, 2006, 28(1): 43-48.

Citation:

Bifunctional Chelate for Radiolabeling of Biotin With[99Tcm(CO)3(H2O)3]+[J]. Journal of Nuclear and Radiochemistry, 2006, 28(1): 43-48.

Bifunctional Chelate for Radiolabeling of Biotin With⁹⁹Tc^m(CO)₃(H₂O)₃⁺

Abstract

A novel tridentate ligand for Re /99Tcm(CO)3(H2O)3+ core, coupled with biotin, is designed and synthesized. Radiolabeling of PLB ligand (PLB =N-α-(2-picolyl)-N-ε-biotinyl-L-lysine methyl ester) with 99Tcm(CO)3(H2O)3+ precursor is carefully investigated, and more than 95% of yield is achieved under optimized condition.

FullText(HTML)

Turn off MathJax

Article Contents