Synthesis and Biodistribution of ~(188)Re-NEMMPTDD

On the basis of synthesizing new ligand of NEMMPTDD (2,2,9,9-tetramethyl-4,7-diaza-4-piperidinyl-ethyl-1,10-decanedithiol),~(188)Re-NEMMPTDD is prepared with the reducing agent of SnCl_2. The biodistribution results show that the lipiodol solution of ~(188)Re-NEMMPTDD exhibits certain uptake and retention in liver and lower uptake and retention in other tissues and is metabolized by kidney, the intestines and stomach.