Synthesis and Biodistribution of Novel Glucose-Dithiocarbamate Derivatives Labelled With ⁹⁹Tc^mN(PNP)^2+

A series of novel glucose-dithiocarbamate derivatives L_n(L₁-L₅) were selected to label with TcN²⁺ using bisphosphines (PNP) as coligands for the new myocardial and tumor imaging agents studies. The radiochemical purity of these complexes were above 90% according to the analysis results of HPLC and TLC. These complexes showed similar biodistribution characteristicswith a lower initial myocardial uptake and a rapid clearance from blood, muscle, liver and other tissues in normal mice. The low tumor accumulation of ⁹⁹Tc^mN(PNP)L₂ complexe appeared in mice xenografted with EMT-6 (0.39±0.03)%ID/g in 30 min after injection.