Synthesis and Fluoro-Radiolabelling of Proliferation Imaging Agent ¹⁸F-FLT 

Synthesis and fluoro-radiolabeling of proliferation imaging agent 3’deoxy3’-¹⁸F-fluorothymidine（¹⁸F-FLT）were reported. The chemical structure of the labeling precursor N-BOC-FLT and all its intermediates were verified by IR, MS and ¹H NMR. Nucleophilic fluorination was proceeded at 120 ℃. Radiochemical yield is （35.2±5.8）% (n=2, decay corrected) and final radiochemical purity is above 95% determined by TLC and HPLC. Thereby it can be used preclinically.