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WANG Wu-shang, ZHANG Jin-ming, LIU Bo-li. Preparation of ［125I］TZDM[J]. Journal of Nuclear and Radiochemistry, 2010, 32(1): 57-60.
Citation: WANG Wu-shang, ZHANG Jin-ming, LIU Bo-li. Preparation of ［125I］TZDM[J]. Journal of Nuclear and Radiochemistry, 2010, 32(1): 57-60.
shu

Preparation of ［125I］TZDM

  • 1.

    Northwest Institute of Nuclear Technology, Xi’an 710024, China

  • 2.

    College of Chemistry, Beijing Normal University, Beijing 100875, China

  • 3.

    Department Nuclear Medicine, the PLA General Hospital, Beijing 100853, China

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  • Received Date: December 31, 1899
  • Revised Date: December 31, 1899
    Graphical Abstract
    • Abstract
  • An excellent Aβ imaging agent must have high affinity for Aβ plaques. The in vitro competition binding assay is an effective method for determining the affinity of unlabelled imaging agents for Aβ plaques. ［125I］TZDM was often used as a radioactive ligand in the assay. In this paper, Bu3Sn-TZDM, a precursor compound of ［125I］TZDM, was synthesized by four steps from 4-bromo-aniline. After the precursor compound was labeled with 125I, crude ［125I］TZDM was obtained. The labelling yield is 62.5%. ［125I］TZDM is separated with HPLC and has more than 97% radiochemical purity. The actual yield is 25%.
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    • References (13)
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