Synthesis and Carbon Labeling of 11C-PIB for Aβ-Amyloid Imaging
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Graphical Abstract
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Abstract
Assessing the deposition of Aβ-amyloid in the living brain is important for diagnosis and treatment of Alzheimer’s disease(AD). 2-(4′-N-11C-methyl-aminophenyl)-6-hydroxybenzothiazole( 11C-PIB) was used as a ideal labeled probe imaging Aβ-amyloid for AD. The precursor of 11C-PIB, 2-(4′-aminophenyl)-6-hydroxybenzothiazole, was synthesized. 11C-PIB was labeled with 11C-CH3-Triflate(Trifluoromethanesulfonate)under unprotect 6-hydroxyl precursor at room temperature. The labeling yield, radiochemistry purity and specific activity are 52.6%(corrected, n=35), 99% and 18.0TBq/mmoL respectively. The by reaction occurrs when the reaction is heated 80℃ for 2 min. The radiochemistry purity can be improved to 99% by semi-HPLC weak acid mobile phase.
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