ZHANG Jin-ming, WANG Wu-shang, ZHANG Xiao-jun, GUO Zhe, TIAN Jia-he. Synthesis and Carbon Labeling of 11C-PIB for Aβ-Amyloid Imaging[J]. Journal of Nuclear and Radiochemistry, 2011, 33(3): 188-192.
    Citation: ZHANG Jin-ming, WANG Wu-shang, ZHANG Xiao-jun, GUO Zhe, TIAN Jia-he. Synthesis and Carbon Labeling of 11C-PIB for Aβ-Amyloid Imaging[J]. Journal of Nuclear and Radiochemistry, 2011, 33(3): 188-192.

    Synthesis and Carbon Labeling of 11C-PIB for Aβ-Amyloid Imaging

    • Assessing the deposition of Aβ-amyloid in the living brain is important for diagnosis and treatment of Alzheimer’s disease(AD). 2-(4′-N-11C-methyl-aminophenyl)-6-hydroxybenzothiazole( 11C-PIB) was used as a ideal labeled probe imaging Aβ-amyloid for AD. The precursor of 11C-PIB, 2-(4′-aminophenyl)-6-hydroxybenzothiazole, was synthesized. 11C-PIB was labeled with 11C-CH3-Triflate(Trifluoromethanesulfonate)under unprotect 6-hydroxyl precursor at room temperature. The labeling yield, radiochemistry purity and specific activity are 52.6%(corrected, n=35), 99% and 18.0TBq/mmoL respectively. The by reaction occurrs when the reaction is heated 80℃ for 2 min. The radiochemistry purity can be improved to 99% by semi-HPLC weak acid mobile phase.
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