Comparison of Biodistribution of Two 99Tcm-Labeled Thymidine Analogs in Mice
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Graphical Abstract
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Abstract
To develop novel technetium-99m-labeled thymidine analog for tumor SPECT imaging, two 99Tcm-labeled thymidine analogs (99Tcm-ANMdU and 99Tcm-NHT) were synthesized. 99Tcm-ANMdU and 99Tcm-NHT are stable in aqueous solution and radiochemical purity are over 95%. Biodistribution of 99Tcm-ANMdU in tumor-bearing mice shows that the high uptake of 99Tcm-ANMdU in kidney and the clearance is fast. At 60min p.i., the ratios of tumor-to-muscle, tumor-to-bone and tumor-to-blood are 1.58±0.17, 1.95±0.31 and 1.17±0.08, respectively. Biodistribution of 99Tcm-NHT in mice shows that the high uptake of 99Tcm-NHT in liver and kidney, indicating that the clearance of 99Tcm-NHT is mainly through the hepatobiliary pathway and the renal pathway. At 2 h p.i., the ratios of tumortomuscle, tumor-to-bone and tumor-to-blood are 4.41±0.32, 2.45±0.24 and 1.51±0.18, respectively. These indicate that 99Tcm-NHT is probably a potential SPECT tumor imaging agent and further study is needed.
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