A Novel Aβ-Amyloid Imaging Agent <sup>18</sup>F-W372 for Alzheimer’s Disease

ZHANG Xiao-jun; FU Li-ping; ZHANG Jin-ming; LI Yun-gang; TIAN Jia-he

doi:10.7538/hhxyfshx.2013.35.01.0040

Journal of Nuclear and Radiochemistry > 2013 > 35(1): 40-45. > DOI: 10.7538/hhxyfshx.2013.35.01.0040

ZHANG Xiao-jun, FU Li-ping, ZHANG Jin-ming, LI Yun-gang, TIAN Jia-he. A Novel Aβ-Amyloid Imaging Agent ¹⁸F-W372 for Alzheimer’s Disease[J]. Journal of Nuclear and Radiochemistry, 2013, 35(1): 40-45. DOI: 10.7538/hhxyfshx.2013.35.01.0040

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A Novel Aβ-Amyloid Imaging Agent ¹⁸F-W372 for Alzheimer’s Disease

Department Nuclear Medicine, The PLA General Hospital, Beijing 100853, China

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Abstract

Abstract

A new Aβ-amyloid imaging agent 7-methoxy-2(6-fluoropyridin-3-yl)imidazo［2,1-b］-8-pyridinothiazol (¹⁸F-W372) is synthesized, the non-decay corrected radiochemical yield is （25.3±7.1）% （n=6）, the radiochemical purity is more than 99.5%, and the specific activity is 659-721PBq/mol. Biodistribution of the ¹⁸F-W372 in mice indicates that uptake is high in brain, the brain is （4.36±1.44）%ID/g at 5min, the washout from normal brain is fast, and the brain is （0.54±0.16）%ID/g at 30min post injection. The acute toxicity test of ¹⁸F-W372 proves its safety in clinical use. The cortical/cerebellar specific uptake is higher in AD patients than in controls at 40min after injection of ¹⁸F-W372. ¹⁸F-W372 may have potential as a Aβ-amyloid imaging agent for Alzheimer’s disease.
- Aβ-amyloid imaging agent,
- ¹⁸F-W372,
- biodistribution in mice

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A Novel Aβ-Amyloid Imaging Agent ¹⁸F-W372 for Alzheimer’s Disease

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A Novel Aβ-Amyloid Imaging Agent ¹⁸F-W372 for Alzheimer’s Disease